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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
Citrate Synthase Activity Assay Kit is a crucial tool in biochemical and pharmaceutical research primarily used to measure the enzymatic activity of citrate synthase an essential enzyme in the citric acid cycle Originating from cellular metabolism studies it aids in understanding the conversion of oxaloacetate and acetyl-CoA to citrate and CoA-SH This reaction plays a pivotal role in energy production and metabolic regulation The kit is commonly used in in vitro assays with activity detectable in nanomolar to low micromolar ranges Applications include use in cellular models animal studies and drug screening to analyze metabolic pathways and potential drug interactions Experimental concentrations typically depend on the specific research design Its precision and reliability make it indispensable for academics and industry professionals investigating metabolic disorders cancer metabolism and mitochondrial function
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COR659 is a potent and effective GABAB positive allosteric modulator (PAM). It suppresses alcohol and chocolate self-administration in rats. It appears to act through a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.
Potent and effective GABAB positive allosteric modulator (PAM).
Suppresses alcohol and chocolate self-administration in rats.
Effective in reducing lever-responses for sucrose and chocolate solutions in rats.
In vivo studies indicate no effect on lever-responding for regular food pellets in food-deprived Wistar rats.
Demonstrates a dose-dependent reduction in lever-responses for alcohol in rats.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase, which catalyzes the second step of de novo pyrimidine biosynthesis. It synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines. It is for research use only and not sold to patients.
DNA antimetabolite agent
Potent inhibitor of aspartate transcarbamoyl transferase
Synergistically enhances the cytotoxicity of 5-FU and IFN against human colon cancer cell lines
Treatment with 490 mg/kg in mice bearing B16 melanoma increased life-span by 77% to 86%
Lewis lung carcinoma is highly sensitive, with treatment leading to a cure in 50% of mice
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More